Related Experiment Video
Updated: May 25, 2026

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
A streamlined synthesis of androstadiene C-17 ester derivatives
Fabrice Gallou1, Manuela Seeger-Weibel, Daniel Lupp
1Chemical and Analytical Development, Novartis Pharma AG, CHBS, WSJ-145.7.52, Novartis Campus, CH-4056 Basel, Switzerland. fabrice.gallou@novartis.com
Abstract:
The development of a fully telescoped synthesis of a derivative of androstadiene C-17 esters made from epoxyparamethasone was demonstrated. This streamlining allowed for the elimination of isolation and solvent change after each synthetic step. Thus it not only drastically reduced the solvent waste, but also minimized the potential exposure to highly active intermediates thereby increasing the overall yield. The intuitively obvious advantage inherent to lowering the number of solvents was illustrated by applying standard green metrics.
More Related Videos
Related Concept Videos
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
α-Hydroxy Ketones via Reductive Coupling of Esters: Acyloin Condensation Overview
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)