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Serological IgG avidity test for ocular toxoplasmosis
Subramaniam Suresh1, Saidin Nor-Masniwati, Muhd Nor Nor-Idahriani
1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Clinical Ophthalmology (Auckland, N.Z.)
|February 1, 2012
Summary
Serological testing for toxoplasmosis, including immunoglobulin (Ig) G avidity, aids in diagnosing ocular inflammation. This helps differentiate between recent infections and reactivation, supporting clinical diagnosis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Immunology
Background:
- Evaluating immunoglobulin (Ig) G avidity in toxoplasmosis serology for ocular inflammation.
- Determining clinical manifestations of ocular toxoplasmosis.
Observation:
- Retrospective review of 130 patients with ocular inflammation (2005-2009).
- Analyzed visual acuity, clinical signs, serological tests, and treatment records.
Findings:
- 54.6% of patients were seropositive for toxoplasmosis.
- IgG avidity testing differentiated recent infection (≤40%) from reactivation (>40%).
- Chorioretinal scarring was more common in seropositive patients (P=0.036).
Implications:
- Toxoplasmosis antibody testing supports clinical diagnosis of ocular toxoplasmosis.
- Differentiates between recent infection and reactivation, guiding treatment.
- Highlights the importance of serological avidity testing in managing ocular inflammation.
