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Published on: January 31, 2018
When less is more: can we abandon prophylactic platelet transfusion in Dengue fever?
Changa Kurukularatne1, Frederico Dimatatac, Diana Lt Teo
1Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
Abstract:
Dengue fever (DF) has several hematological manifestations including thrombocytopenia and increased bleeding risk. Prophylactic platelet transfusion-in the absence of major bleeding-is utilized in DF with thrombocytopenia with the intention of preventing hemorrhagic complications. However, prophylactic platelet transfusion in DF is neither standardized nor supported by clinical evidence. We conclude that risks, costs and poor resource utilization associated with prophylactic platelet transfusion in DF far outweigh any potential hematological benefit, and as such, should not constitute routine clinical practice.
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