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09:01
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
Published on: June 26, 2020
A new inositol derivative from Prenanthes macrophylla
Yong-Hong Zhang1, Yong-Sheng Chen, Xiao-Yan Lin
1School of Pharmacy, Fujian Medical University, Fuzhou, China. zhangyh@mail.fjmu.edu.cn
Journal of Asian Natural Products Research
|February 3, 2012
Summary
A novel chiro-inositol ester was isolated from Prenanthes macrophylla Franch. This study details its structure and identifies ten additional known compounds from the plant.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
Background:
- Prenanthes macrophylla Franch. is a plant species with potential medicinal properties.
- Investigating the chemical constituents of medicinal plants is crucial for discovering new bioactive compounds.
Purpose of the Study:
- To isolate and characterize novel and known compounds from Prenanthes macrophylla Franch.
- To elucidate the structures of these compounds using advanced spectroscopic techniques.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS), Electrospray Ionization Mass Spectrometry (ESI-MS), Nuclear Magnetic Resonance (NMR) spectroscopy (1H, 13C, HSQC, HMBC, ROESY).
- Confirmation through chemical evidence.
Main Results:
- A new chiro-inositol ester, 4-hydroxyphenylacetyl-3-d-chiro-inositol ester (1), was identified.
- Ten known compounds were isolated and identified: 4-hydroxyphenylacetic acid (2), trans-ethyl caffeate (3), cis-ethyl caffeate (4), protocatechualdehyde (5), luteolin (6), luteolin-7-O-β-d-glucoside (7), and guaianolides (8, 9), ursolic acid (10), and oleanolic acid (11).
Conclusions:
- The chemical investigation of Prenanthes macrophylla Franch. led to the discovery of a new chiro-inositol ester.
- The study expands the knowledge of the phytochemical profile of this plant species.
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