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Updated: May 25, 2026
Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Comparison of contrast media and low-molecular-weight dextran for frequency-domain optical coherence tomography
Yuichi Ozaki1, Hironori Kitabata, Hiroto Tsujioka
1Department of Cardiovascular Medicine, Wakayama Medical University, Wakayama, Japan.
Background:
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may lead to the impairment of renal function. The safety and usefulness of the non-occlusion method with low-molecular-weight dextran L (LMD-L) via a guiding catheter for TD-OCT image acquisition have been reported previously. The aim of the present study was to compare the image quality and quantitative measurements between contrast media and LMD-L for FD-OCT image acquisition in coronary stented lesions.
Methods And Results:
Twenty-two patients with 25 coronary stented lesions were enrolled in this study. FD-OCT was performed with the continuous-flushing method via a guiding catheter. Both contrast media and LMD-L were infused at a rate of 4 ml/s by an autoinjector. With regard to image quality, the prevalence of clear image segments was comparable between contrast media and LMD-L (97.9% vs. 96.5%, P=0.90). Furthermore, excellent correlations were observed between both flushing solutions in terms of minimum lumen area, mean lumen area, and mean stent area. The total volumes of contrast media and of LMD-L needed for OCT image acquisition were similar.
Conclusions:
FD-OCT image acquisition with LMD-L has the potential to reduce the total amount of contrast media without loss of image quality.
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