Related Experiment Videos
Immunization against experimental visceral toxocariasis canis
1Department of Parasitology, Faculty of Medicine, Mansoura University, A.R.E.
Journal of the Egyptian Society of Parasitology
|December 1, 1990
Summary
Immunizing rabbits with Toxocara canis larval glycoproteins reduced parasite burden and increased IgE levels. Higher inoculation doses of T. canis eggs led to greater larval burden reduction in immunized rabbits.
Area of Science:
- Veterinary Immunology
- Parasitology
- Infectious Diseases
Background:
- Visceral toxocariasis, caused by Toxocara canis infection, poses a significant health concern.
- Developing effective immunization strategies is crucial for controlling parasitic infections.
Purpose of the Study:
- To evaluate the efficacy of immunization using T. canis larval glycoproteins against visceral toxocariasis in rabbits.
- To assess the impact of immunization on parasite burden and host immune response, specifically serum IgE levels.
Main Methods:
- Rabbits were immunized with T. canis larval glycoproteins.
- Immunized and control rabbits were subsequently infected with T. canis.
- Larval burden and serum IgE levels were measured and compared between groups.
Main Results:
- Immunization with T. canis larval glycoproteins significantly reduced larval burden in infected rabbits compared to controls.
- A significant rise in serum IgE was observed in immunized rabbits post-infection.
- Higher doses of T. canis larvated eggs resulted in a more pronounced reduction of larval burden in immunized animals.
Conclusions:
- T. canis larval glycoproteins show promise as a vaccine candidate for preventing visceral toxocariasis.
- The observed increase in IgE suggests an effective immune response mediated by the immunization.