Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obsessive-Compulsive Disorder

Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...

Personality Disorders: Dependent and Obsessive-Compulsive

Personality Disorders: Dependent and Obsessive-Compulsive

Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
Dependent Personality Disorder
Dependent personality disorder is characterized by an excessive reliance on others to manage various aspects of life. Individuals with this disorder often struggle with...

Anxiety: Overview

Anxiety: Overview

Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.

Oppositional Defiant Disorder

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...

Panic Disorder

Panic Disorder

Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...

Binge Eating Disorders

Binge Eating Disorders

Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The value of mental science: we publish what matters.

The British journal of psychiatry : the journal of mental science·2025

Same author

Obsessive compulsive disorder in children and adolescents: duration of maintenance drug treatment.

BMJ clinical evidence·2015

Same author

Deliberate self-harm (and attempted suicide).

BMJ clinical evidence·2015

Same author

Obsessive compulsive disorder.

BMJ clinical evidence·2009

Same author

Deliberate self-harm (and attempted suicide).

BMJ clinical evidence·2009

Same author

Obsessive compulsive disorder.

Clinical evidence·2006

Search research articles

Related Experiment Video

Updated: May 25, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Obsessive compulsive disorder.

G Mustafa Soomro¹

¹St. James Hospital, Portsmouth, UK.

BMJ Clinical Evidence

|February 7, 2012

Summary

This summary is machine-generated.

This systematic review evaluates treatments for obsessive compulsive disorder (OCD). It found various interventions, including behavioral therapy and serotonin reuptake inhibitors, effective for adults and children with OCD.

More Related Videos

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Related Experiment Videos

Last Updated: May 25, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Protocol for Repetitive Transcranial Magnetic Stimulation with Symptom Provocation to Treat Obsessive-compulsive Disorder

Published on: November 25, 2025

Area of Science:

Psychiatry and Behavioral Sciences
Clinical Psychology
Pharmacology

Background:

Obsessive compulsive disorder (OCD) affects 1-1.5% of adults and 2.7% of children/adolescents.
OCD can have an episodic or continuous course, persisting in 40% of youth.
The disorder causes significant personal distress and social dysfunction.

Purpose of the Study:

To systematically review the effects of initial and maintenance treatments for OCD in adults.
To assess treatments for children and adolescents with OCD.
To evaluate interventions for adults with SRI-resistant OCD.

Main Methods:

Systematic review of 43 studies including systematic reviews, RCTs, and observational studies.
Searched major databases (Medline, Embase, Cochrane Library) up to April 2011.
Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

Evaluated the effectiveness and safety of numerous interventions for OCD.
Included treatments such as antipsychotics, behavioral therapy, CBT, ECT, psychosurgery, SRIs, and TMS.
Utilized GRADE evaluation for evidence quality.

Conclusions:

Information on the effectiveness and safety of various OCD interventions is presented.
The review covers treatments for different patient groups and treatment stages.
Evidence supports a range of therapeutic options for managing OCD.