Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

From Cortical Impact to Inattention: Real-Time Acetylcholine Disruption Links Brain Trauma to Attentional Deficits.

Journal of neurotrauma·2026

Same author

A consensus roadmap for post-traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials.

Epilepsia·2026

Same author

PRECISE TBI Model Catalog: Increasing Accessibility and Reproducibility in TBI research.

bioRxiv : the preprint server for biology·2026

Same author

Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI.

Molecular neurobiology·2026

Same author

A decade of progress (2014-2025): Environmental enrichment as a validated preclinical model of neurorehabilitation for traumatic brain injury.

Neural regeneration research·2026

Same author

Bridging the gap: Acute amantadine augments the neurorehabilitative efficacy of delayed and abbreviated environmental enrichment in a pediatric traumatic brain injury model.

Brain research·2025

Same journal

Neuroprotective Drugs in Traumatic CNS Injury.

The open drug discovery journal·2025

Same journal

Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death.

The open drug discovery journal·2013

Same journal

The Protective Effects of Ischemic Postconditioning against Stroke: From Rapid to Delayed and Remote Postconditioning.

The open drug discovery journal·2011

Same journal

Estrogen and P2 Purinergic Receptor Systems in Microglia: Therapeutic Targets for Neuroprotection.

The open drug discovery journal·2011

See all related articles

Search research articles

Related Experiment Video

Updated: May 25, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Targeting Dopamine in Acute Traumatic Brain Injury.

James W Bales¹, Anthony E Kline, Amy K Wagner

¹Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, USA.

The Open Drug Discovery Journal

|February 7, 2012

Summary

This summary is machine-generated.

Traumatic brain injury (TBI) causes secondary damage. This review explores how targeting dopamine signaling pathways may offer neuroprotection and improve functional outcomes after TBI.

More Related Videos

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

Published on: January 30, 2018

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

Related Experiment Videos

Last Updated: May 25, 2026

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

Detecting Behavioral Deficits in Rats After Traumatic Brain Injury

Published on: January 30, 2018

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging

Published on: April 6, 2014

Area of Science:

Neuroscience
Neurology
Pharmacology

Background:

Traumatic brain injury (TBI) involves initial mechanical damage and secondary insults like excitotoxicity, metabolic disruption, and oxidative stress.
Current neuroprotective strategies often focus on cellular preservation, but functional deficits persist even with neuronal sparing.
Effective TBI therapies require strategies that promote both neuronal survival and post-injury functional recovery.

Purpose of the Study:

To review the role of dopamine in acute TBI.
To discuss the potential of dopaminergic therapies as neuroprotective strategies for TBI.

Main Methods:

Literature review of studies investigating dopamine's role in TBI.
Analysis of research on dopaminergic signaling pathways in the context of neuroprotection and functional recovery.

Main Results:

Dopamine signaling is implicated in TBI pathophysiology, influencing inflammation, oxidative stress, and cellular dysfunction.
Dysregulation of dopamine levels (depletion or over-expression) can exacerbate TBI-induced damage.
Targeting dopaminergic pathways presents a novel therapeutic avenue for TBI.

Conclusions:

Dopaminergic therapies offer a promising approach for TBI treatment by potentially enhancing both neuronal survival and functional outcomes.
Further research into modulating dopamine signaling is warranted for developing improved clinical TBI interventions.