Neuroprotective Drugs in Traumatic CNS Injury

Despite extensive experimental research, the numbers of neuroprotective drugs that have proven efficacy following treatment of patients with traumatic CNS injuries still remain meager. It would be worthwhile to emphasize that majority of the victims are mostly in the second or third decades of their lives. A survey on the neuroprotective molecules that has been tested experimentally and subsequently tried clinically has been found somewhat beneficial. In the present review, we consolidated the updates on a number of such drugs, which hold promise for therapy of traumatic CNS injuries. Two such agents, endogenous molecules estrogen and melatonin have been under investigation in our laboratory for their efficacy in experimental spinal cord injury in rats.