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Related Concept Videos

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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Related Experiment Video

Updated: May 25, 2026

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Finding the BOLD effect in brain images.

Seiji Ogawa1

  • 1Kansei Fukushi Research Center, Tohoku Fukushi University, 6-149-1 Kunimigaoka, Aobaku, Sendai 9893201, Japan. s.ogawa33@nifty.com

Neuroimage
|February 8, 2012
PubMed
Summary
This summary is machine-generated.

Researchers recall the events leading to the discovery of the Blood-Oxygen-Level-Dependent (BOLD) effect in brain imaging. This historical account focuses on the author's perspective before 1992.

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Last Updated: May 25, 2026

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Area of Science:

  • Neuroimaging
  • Biomedical Engineering
  • Radiology

Background:

  • Recounts the historical context and intellectual journey preceding the discovery of the Blood-Oxygen-Level-Dependent (BOLD) effect.
  • Focuses on the author's personal recollections and thought processes from the pre-1992 era.

Observation:

  • Details the sequence of events and conceptual developments that culminated in the identification of the BOLD signal.
  • Highlights the foundational period for functional magnetic resonance imaging (fMRI) techniques.

Findings:

  • Presents a narrative of the discovery of the BOLD effect, a cornerstone of modern neuroimaging.
  • Emphasizes the early conceptualization and experimental considerations that paved the way for BOLD imaging.

Implications:

  • Provides historical insight into a pivotal moment in neuroscience and medical imaging technology.
  • Underscores the importance of understanding the origins of key scientific findings for future research.