The validity of biochemical markers in metabolic bone disease in preterm infants: a systematic review
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Updated: May 25, 2026
13:13
Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
Fenna Visser1, Arwen J Sprij, Frank Brus
1Department of Paediatrics, Juliana Children's Hospital, The Hague, The Netherlands. f.visser@amc.uva.nl
Acta Paediatrica (Oslo, Norway : 1992)
|February 9, 2012
Abstract
Unlabelled:
To establish the validity of biochemical markers of metabolic bone disease (MBD) in preterm infants.
Conclusion:
There is insufficient evidence that any of the frequently used serum measurements are valid biochemical markers of MBD in preterm infants. Increased urinary calcium concentration may be a valid biochemical marker, but more research is necessary to confirm this.
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