Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case 17-2026: A 74-Year-Old Man with Pancytopenia.

The New England journal of medicine·2026
Same author

Form Follows Function: Introducing a Comparative Hematology Course into the Post-Clerkship Phase of Medical School.

Medical science educator·2025
Same author

Icefish: Peculiar Creatures Without Hemoglobin or Red Blood Cells.

Mayo Clinic proceedings·2025
Same author

Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.

Nature·2024
Same author

Single platelet and megakaryocyte morpho-dynamics uncovered by multicolor reporter mouse strains <i>in vitro</i> and <i>in vivo</i>.

Haematologica·2021
Same author

New Uses for Thromboelastography and Other Forms of Viscoelastic Monitoring in the Emergency Department: A Narrative Review.

Annals of emergency medicine·2020
Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026
Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026
Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026
Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026
Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026
See all related articles

Related Experiment Video

Updated: May 25, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
10:15

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Endothelial cell heterogeneity.

William C Aird1

  • 1Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. waird@bidmc.harvard.edu

Cold Spring Harbor Perspectives in Medicine
|February 9, 2012
PubMed
Summary
This summary is machine-generated.

Endothelial cells in blood vessels vary greatly. Understanding these differences offers insights into targeted therapies, especially for tumor blood vessels.

More Related Videos

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Related Experiment Videos

Last Updated: May 25, 2026

Isolation and Culture Expansion of Tumor-specific Endothelial Cells
10:15

Isolation and Culture Expansion of Tumor-specific Endothelial Cells

Published on: October 14, 2015

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications
09:00

Isolation and Identification of Vascular Endothelial Cells from Distinct Adipose Depots for Downstream Applications

Published on: June 10, 2022

Area of Science:

  • Vascular biology
  • Cellular heterogeneity
  • Molecular mechanisms

Background:

  • Endothelial cells form the inner lining of blood vessels.
  • Significant variations exist in endothelial cell structure and function across different vascular beds.
  • These variations change over time, space, and in response to health and disease states.

Purpose of the Study:

  • To review the extent of endothelial heterogeneity.
  • To discuss the underlying proximate and evolutionary mechanisms driving this heterogeneity.
  • To explore the therapeutic implications of endothelial heterogeneity, particularly in disease.

Main Methods:

  • Literature review of endothelial cell heterogeneity.
  • Analysis of proximate and evolutionary mechanisms.
  • Application of principles to tumor endothelium.

Main Results:

  • Endothelial heterogeneity is a fundamental characteristic of blood vessels.
  • Mechanisms driving heterogeneity are diverse and contribute to functional specialization.
  • Tumor endothelium exhibits distinct characteristics that can be targeted therapeutically.

Conclusions:

  • Understanding endothelial phenotypic heterogeneity is crucial for developing targeted vascular therapies.
  • Therapeutic strategies can be tailored based on the specific characteristics of endothelial cells in different vascular beds.
  • Targeting tumor endothelium presents a promising avenue for cancer treatment.