Related Experiment Video
Updated: May 25, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Difference in morning and evening choroidal thickness in Japanese subjects with no chorioretinal disease
Noriko Toyokawa1, Hideya Kimura, Atsuko Fukomoto
1Nagata Eye Clinic, Nara, Japan. noritama0620@topaz.ocn.ne.jp
Background And Objective:
To determine whether the choroidal thickness varies significantly according to the time of measurement in Japanese subjects without chorioretinal diseases.
Patients And Methods:
Twelve eyes of 12 subjects were examined with enhanced depth imaging spectral-domain optical coherence tomography. The choroidal thickness was measured in the mornings (9:00 to 9:30 AM) and evenings (7:30 to 8:00 PM) at three locations: the fovea, 1.5 mm temporal to the fovea, and 1.5 mm nasal to the fovea.
Results:
The mean age of the subjects was 62.6 ± 14.5 years. For the morning measurements, the mean choroidal thickness was 308.5 ± 74.4 μm at the fovea, 276.2 ± 84.6 μm temporally, and 239.3 ± 98.4 μm nasally. For the evening measurements, the mean choroidal thickness was 328.8 ± 85.6 μm at the fovea, 284.8 ± 91.6 μm temporally, and 248.9 ± 101.5 μm nasally. The mean subfoveal (P < .0001) and nasal (P = .03) choroidal thicknesses were significantly thicker in the evenings than in the mornings. There was no significant difference in the mean temporal choroidal thickness (P = .08).
Conclusion:
The choroidal thickness varies according to the time of measurement.