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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Related Experiment Video

Updated: May 25, 2026

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
05:10

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells

Published on: July 11, 2025

Recent progress toward understanding the physiological function of bone marrow mesenchymal stem cells.

Chao Shi1

  • 1Immunology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. cshi@rockefeller.edu

Immunology
|February 11, 2012
PubMed
Summary

Mesenchymal stem cells (MSCs) are explored for regenerative therapy due to their immune-modulating factors. This review highlights bone marrow MSC functions in blood formation and immune responses, despite challenges in in vivo identification.

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Last Updated: May 25, 2026

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
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Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells

Published on: July 11, 2025

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Isolation and Cultivation of Mandibular Bone Marrow Mesenchymal Stem Cells in Rats

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Area of Science:

  • Stem cell biology
  • Immunology
  • Regenerative medicine

Background:

  • Mesenchymal stem cells (MSCs) are multipotent cells with clinical potential for regenerative therapies.
  • MSCs secrete factors mediating immunosuppressive effects, crucial for their therapeutic applications.
  • In vivo identification of MSCs remains challenging due to a lack of specific markers.

Purpose of the Study:

  • To review the diverse functions of mesenchymal stem cells (MSCs) in vivo.
  • To focus on bone marrow MSCs and their roles in hematopoiesis and immune responses.
  • To discuss recent advances in murine MSC research for in vivo studies.

Main Methods:

  • Literature review of current research on mesenchymal stem cells.
  • Analysis of findings related to MSC localization and function in vivo.
  • Focus on studies utilizing murine models.

Main Results:

  • MSCs exert varied functions influenced by tissue context and physiological conditions.
  • Bone marrow MSCs play significant roles in hematopoiesis (blood formation).
  • MSCs are involved in modulating immune responses.

Conclusions:

  • Mesenchymal stem cells offer therapeutic promise, particularly through their secreted factors.
  • Understanding MSCs' in vivo functions, especially in bone marrow, is critical for regenerative medicine.
  • Advances in murine models are crucial for elucidating MSC behavior and therapeutic potential.