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Updated: May 25, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Isolation of tumor suppressor genes in melanoma by cDNA microarray
1Department of Oncology, Institute for Molecular and Human Genetics, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC.
Abstract:
The multistep genetic alterations thought to involve both oncogenes and tumor suppressor genes that are causally related to melanocytic transformation remain largely undetermined (1). Mapping of alterations to chromosome 6 indicates that multiple genetic loci on 6q contribute causally to the development and progression of malignant melanoma (1). This notion is also supported by the introduction of chromosome 6 in malignant melanoma cell lines suppressing either their tumorigenicity (2) or metastasis (3,4). However, the suppressor genes involved have yet to be identified.
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