Related Experiment Video
Updated: May 24, 2026

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
Infants and Young Children with Children's Interstitial Lung Disease
Insights
Children's interstitial lung disease (chILD) affects infants and young children, presenting unique diagnostic challenges. Early identification and diagnosis are crucial for appropriate management of these rare lung disorders.
Area of Science:
- Pediatric Pulmonology
- Neonatology
- Rare Diseases
Background:
- Interstitial lung disease (ILD) in children, particularly infants, represents a distinct group of disorders.
- These conditions are linked to lung development and injury, differing from adult ILD.
- Increased attention is given to infantile ILD due to its unique characteristics and impact.
Purpose of the Study:
- To highlight the importance of identifying and diagnosing children's interstitial lung disease (chILD).
- To review specific chILD disorders common in infancy.
- To discuss the presentation, evaluation, treatment, and clinical course of these conditions.
Main Methods:
- Review of specific infantile chILD disorders including diffuse developmental disorders, growth abnormalities, pulmonary interstitial glycogenosis, neuroendocrine cell hyperplasia of infancy, and surfactant dysfunction mutations.
- Discussion of presentation, evaluation, and treatment strategies.
- Brief mention of less common categories and available resources.
Main Results:
- Specific infantile chILD disorders require specialized recognition by pediatric specialists.
- Early diagnosis is critical for effective management and improved outcomes.
- A range of disorders, from developmental to genetic, fall under the chILD umbrella.
Conclusions:
- Recognizing and diagnosing chILD is essential for pediatric pulmonologists, neonatologists, radiologists, and pathologists.
- Specific infantile disorders like pulmonary interstitial glycogenosis and surfactant dysfunction mutations necessitate tailored approaches.
- Resources are available to support physicians and families dealing with chILD.
Abstract:
Though interstitial lung disease (ILD) can occur at any age in children, disorders more common in infancy and young children have received increased attention as an important group that is disproportionally affected, linked to lung development and lung injury, and represents disorders not seen in adult ILD. Identifying those children with potential children's ILD (chILD) and establishing a specific chILD diagnosis has evolved and is critical for pediatric pulmonologists, neonatologists, radiologists, and pathologists to recognize. Specific disorders more common in infancy include diffuse developmental disorders, growth abnormalities, pulmonary interstitial glycogenosis, neuroendocrine cell hyperplasia of infancy, and surfactant mutation dysfunction mutations. The presentation, evaluation, treatment, and clinical course are discussed for each of these specific disorders and other categories less common in infants and young children are briefly mentioned. Resources for physicians and families are also reviewed.
Related Concept Videos
Pulmonary Cycle: Exhalation
Breathing
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia I: Introduction
Drug Dosing: Infants and Children