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Updated: May 24, 2026

Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Synthesis, computational, spectroscopic, thermal and antimicrobial activity studies on some metal-urate complexes
Mamdouh S Masoud1, Alaa E Ali, Medhat A Shaker
1Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. drmsmasoud@yahoo.com
Abstract:
New sixteen uric acid metal complexes of different stoichiometry, stereo-chemistries and modes of interactions were synthesized using different metals Cr, Mn, Fe, Co, Ni, Cu, Cd, UO(2), Na and K. The synthesized complexes were characterized by elemental analysis, spectral (IR, UV-Vis and ESR) methods, thermal analysis (TG, DTA and DSC) and magnetic susceptibility studies. Molecular modeling calculations were used to characterize the ligation sites of the free ligand. Furthermore, quantum chemical parameters of uric acid such as the energies of highest occupied molecular orbital (E(HOMO)), energies of lowest unoccupied molecular orbital (E(LUMO)), the separation energy (ΔE=E(LUMO)-E(HOMO)), the absolute electronegativity, χ, the chemical potential, P(i), the absolute hardness, η and the softness (σ) were obtained for uric acid. Eight different microbial categories were used to study the antimicrobial activity of the free ligand and ten of its complexes. The results indicate that the ligand and its metal complexes possess antimicrobial properties. The stoichiometry of iron-uric acid complex was studied by using different spectrophotometric methods.
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