Related Experiment Video
Updated: May 24, 2026

06:04
Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Empyema caused by Mycoplasma salivarium
Rafael Baracaldo1, Michael Foltzer, Robin Patel
1Divisions of Medicine, Geisinger Medical Center, Danville, Pennsylvania, USA.
Journal of Clinical Microbiology
|February 17, 2012
Summary
Mycoplasma salivarium, a bacterium typically found in the mouth, rarely causes infections elsewhere. This report details the first known case of empyema (a type of pleural space infection) caused by this pathogen.
Area of Science:
- Microbiology
- Infectious Diseases
- Pulmonology
Background:
- Mycoplasma salivarium is a commensal bacterium of the human oral cavity.
- Infections caused by M. salivarium outside the oral cavity are exceptionally rare.
- Laryngeal cancer can predispose patients to various infections.
Observation:
- A 49-year-old male patient with laryngeal cancer presented with a right pleural space infection.
- M. salivarium was identified as the causative agent of the pleural infection.
- The patient's clinical presentation and microbiological findings were consistent with empyema.
Findings:
- This case represents the first documented instance of empyema caused by Mycoplasma salivarium.
- The findings expand the known spectrum of M. salivarium pathogenicity.
- The successful treatment of the empyema highlights the importance of identifying the specific pathogen.
Implications:
- This report underscores the potential for oral commensals to cause severe, invasive infections in immunocompromised or debilitated patients.
- Further research may be warranted to understand the mechanisms by which M. salivarium can disseminate to the pleural space.
- Clinicians should consider M. salivarium in the differential diagnosis of pleural infections, particularly in patients with risk factors such as laryngeal cancer.
Related Concept Videos
Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Bacterial Phylum Tenericutes
The phylum Tenericutes, which includes the single class Mollicutes, comprises bacteria that lack cell walls. The term "Mollicutes" derives from the Latin word mollis, meaning "soft." These organisms are among the smallest known and are commonly referred to as mycoplasmas due to the prominence of the genus Mycoplasma, which includes well-known human pathogens. Despite their inability to stain gram-positively (a result of their lack of cell walls), mycoplasmas are phylogenetically related to the...
Pneumonia I: Introduction
Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Pneumonia III: Complications and Assessment
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
