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Updated: May 24, 2026

Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
[Herpetic endotheliitis and trabeculitis with delayed corneal involvement]
I Carrillo-Arroyo1, E Gutiérrez-Díaz, E Mencía-Gutiérrez
1Servicio de Oftalmología, Hospital 12 de Octubre, Universidad Complutense, Madrid, España.
Case Report:
A 62-year-old man with previous renal transplant and immunosuppressive treatment presented with decreased visual acuity (20/100) in his left eye, corneal oedema and intraocular pressure of 46 mmHg. One month later an inferior marginal dendritic keratitis appeared. Corneal scraping and real-time polymerase chain reaction showed herpes simplex virus (HSV).
Discussion:
The autoimmune corneal endotheliopathy or acute idiopathic corneal endotheliitis is characterised by corneal stromal oedema and keratic precipitates. HSV might be secreted from the trabeculum, innervated by the trigeminal nerve. This hypothesis is supported by the clinical observation that the corneal stromal oedema usually starts from the periphery.
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