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Related Concept Videos

Cognitive Theories: Lazarus Mediational Theory of Emotion01:17

Cognitive Theories: Lazarus Mediational Theory of Emotion

Richard Lazarus' cognitive mediational theory highlights the pivotal role of cognitive appraisal in shaping emotional responses. According to this theory, the evaluation of a stimulus — based on personal values, goals, beliefs, and expectations — mediates the emotional response. This appraisal process is immediate and often occurs unconsciously, influencing the intensity and nature of the resulting emotion.
Cognitive Appraisal and Emotional Response
Lazarus proposed that emotions are not solely...
Structuralism01:26

Structuralism

Structuralism, an early psychological theory developed by Wilhelm Wundt and his student Edward Bradford Titchener, sought to dissect the human mind into its most fundamental components. Wundt's groundbreaking work in his laboratory set the stage for Titchener to define structuralism's goal as cataloging the "atoms" of the mind—sensations, images, and feelings—akin to how chemists identify elements of matter.
Titchener's approach to structuralism was unique. He employed introspection, a method...
Actor-Observer Effect01:23

Actor-Observer Effect

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Structural Protein Function01:56

Structural Protein Function

Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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Structural Protein Function01:56

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Impression Management Techniques IV: Altercasting

Altercasting is a strategic communication technique in which an individual imposes a specific identity or social role onto another person to influence their behavior and shape the interaction. By presuming a role—such as “responsible leader” or “patient person”—altercasting encourages the target to conform to that identity, often aligning their behavior with the expectations associated with the role. The power of this tactic lies in its subtlety; once a role is assigned, it becomes socially...

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Related Experiment Video

Updated: May 24, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

A structural perspective on Mediator function.

Laurent Larivière1, Martin Seizl, Patrick Cramer

  • 1Gene Center and Department of Biochemistry, Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377 Munich, Germany.

Current Opinion in Cell Biology
|February 21, 2012
PubMed
Summary
This summary is machine-generated.

The Mediator complex is crucial for gene transcription but its structure is largely unknown. Further structural studies are needed to understand its role in gene regulation.

Related Experiment Videos

Last Updated: May 24, 2026

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

Area of Science:

  • Molecular Biology
  • Structural Biology
  • Gene Regulation

Background:

  • The Mediator complex is essential for RNA polymerase II-mediated gene transcription.
  • Despite its importance, Mediator's molecular mechanisms are poorly understood due to its large size and flexibility.
  • Previous structural studies have been limited in resolving the complete Mediator structure.

Purpose of the Study:

  • To review available structural data on the Mediator complex.
  • To discuss the functional implications of existing structural information.
  • To identify knowledge gaps in Mediator structure and function.

Main Methods:

  • Systematic collection and analysis of existing structural data on the Mediator complex.
  • Review of literature on Mediator interactions with transcriptional regulators and general transcription machinery.

Main Results:

  • Progress has been made in understanding Mediator interactions with regulatory proteins.
  • Approximately 80% of the Mediator structure remains unresolved.
  • Specific details regarding the Mediator-RNA polymerase II interface are lacking.

Conclusions:

  • Significant gaps remain in our understanding of Mediator's overall structure and its direct interaction with RNA polymerase II.
  • An integrated structural biology approach is proposed to elucidate Mediator's functional architecture.
  • Understanding Mediator's structure is key to deciphering a fundamental mechanism of gene regulation.