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Updated: May 24, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Dopa responsive insomnia: a forme fruste or precursor of restless legs syndrome?
1Department of Neurology, Medical College, SSG Hospital, Baroda, Gujarat, 390001, India. drprakashs@yahoo.co.in
Abstract:
Restless leg syndrome (RLS) is a movement disorder that has a profound impact on sleep, and sleep disturbances are considered as the primary morbidity for seeking treatment in most patients. However, isolated sleep has not been described as a symptom of RLS. Low dose dopaminergic agonists are considered for the treatment in patients with RLS. Herein, we describe 7 patients with isolated insomnia in whom insomnia responded to low dose levo-dopa. Six of them had a family history of RLS. We discuss a possibility of RLS in these patients and suggest to take a trial of l-dopa in patients with isolated insomnia who has a positive family history of RLS or in a patient who do not show response to usual therapies for RLS.
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