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Structural intermediates during α-synuclein fibrillogenesis on phospholipid vesicles.

Gemma Comellas1, Luisel R Lemkau, Donghua H Zhou

  • 1Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Journal of the American Chemical Society
|February 23, 2012
PubMed
Summary

Alpha-synuclein (AS) fibrils convert from helical to β-sheet structures, with or without lipids. Anionic phospholipids alter the N-terminal domain of AS fibrils, impacting Parkinson's disease pathology.

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