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Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA

Harith Jabbar Fahad Al-Mathkhury1, Saba Nazeih Abdul-Ghaffar

  • 1Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.

North American Journal of Medical Sciences
|February 25, 2012
PubMed
Abstract

Insights

Bacterial DNA causes more severe kidney damage than fungal DNA in mice. This study investigated the histopathological changes induced by microbial DNA, highlighting differences in inflammatory responses.

Area of Science:

  • Microbiology
  • Immunology
  • Pathology

Background:

  • Bacterial DNA released during cell death triggers inflammatory responses and tissue damage.
  • Understanding the specific effects of microbial DNA is crucial for managing infections.

Purpose of the Study:

  • To compare the histopathological changes induced by bacterial DNA (Staphylococcus aureus) and fungal DNA (Candida albicans).
  • To elucidate the differential inflammatory potential of prokaryotic versus eukaryotic DNA in a murine model.

Main Methods:

  • Isolates of Staphylococcus aureus and Candida albicans were obtained from patients with urinary tract infections.
  • Viable cells and DNA from antibiotic-sensitive isolates were injected intraurethrally into mice.
  • Histopathological examinations were performed to evaluate tissue responses.

Main Results:

  • Mice challenged with viable Candida albicans showed milder reactions than those challenged with viable Staphylococcus aureus.
  • Both bacterial and fungal DNA induced dose-dependent histological changes.
  • Candida albicans DNA caused less intense histological changes compared to Staphylococcus aureus DNA.

Conclusions:

  • Microbial DNA can induce damage in the murine renal system.
  • Bacterial DNA demonstrated a greater capacity for causing tissue damage than fungal DNA.
Keywords:
DNAStaphylococcus aureusUTIcandida albicans

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