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Effect of Grade I and II intraventricular hemorrhage on visuocortical function in very low birth weight infants

Ashima Madan1, Anthony M Norcia, Chuan Hou

  • 1Stanford University School of Medline, Stanford, CA 94305, USA.

Seeing and Perceiving
|February 29, 2012
PubMed

Insights

Very low birth weight infants with Grade I/II intraventricular hemorrhage (IVH) show impaired cortical vision. These infants exhibit worse visual acuity and contrast sensitivity compared to those without IVH, indicating lasting effects on visual development.

Area of Science:

  • Neonatal Neurology
  • Developmental Neuroscience
  • Ophthalmology

Background:

  • Neurological outcomes for infants with Grade I/II intraventricular hemorrhage (IVH) remain a subject of debate.
  • Understanding the long-term effects of early brain injury on visual development is crucial for VLBW infants.

Purpose of the Study:

  • To investigate whether very low birth weight (VLBW) infants with Grade I/II IVH exhibit altered visuocortical activity compared to VLBW infants without IVH.
  • To assess the impact of mild intraventricular hemorrhage on visual function in preterm infants.

Main Methods:

  • Quantitative swept parameter visual evoked potential (sVEP) responses were measured in VLBW infants using three distinct visual stimuli.
  • Comparison of acuity thresholds and suprathreshold response amplitudes between infants with and without Grade I/II IVH at 5-7 months corrected age.

Main Results:

  • Infants with Grade I/II IVH demonstrated significantly worse grating acuity (GA), contrast sensitivity (CS), and vernier acuity (VA) compared to controls.
  • The slopes of response amplitude for CS and VA were significantly reduced in the IVH group.
  • A downward shift in the spatial frequency tuning function was observed in infants with IVH.

Conclusions:

  • Grade I/II intraventricular hemorrhage is associated with detrimental effects on the development and function of cortical vision.
  • Early mild IVH can lead to persistent visual processing deficits in very low birth weight infants.

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