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Updated: May 24, 2026
09:53
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
Secreted miRNAs suppress atherogenesis
Daniel J Rader1, Michael S Parmacek
1Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11-125 Translational Research Center, Philadelphia, Philadelphia 19104-5156, USA. rader@mail.med.upenn.edu
Nature Cell Biology
|March 1, 2012
Summary
This study shows that microRNAs (miRNAs) transfer between cells via extracellular vesicles. This intercellular miRNA transport protects against atherosclerosis, a cardiovascular disease.
Area of Science:
- Cardiovascular Biology
- Cellular Communication
- Molecular Medicine
Background:
- Endothelial-vascular smooth muscle cell (VSMC) communication is vital for cardiovascular health.
- Dysfunctional cell communication contributes to atherosclerosis pathogenesis.
Purpose of the Study:
- To investigate the role of extracellular vesicle (EV)-mediated microRNA (miRNA) transfer in endothelial-VSMC communication.
- To determine if specific miRNAs transferred between these cells impact atherosclerosis.
Main Methods:
- Analysis of EV-mediated transfer of specific miRNAs (miR-143/145) between endothelial cells and VSMCs.
- Assessment of the atheroprotective effects of transferred miRNAs.
Main Results:
- Demonstrated extracellular-vesicle-mediated transfer of atheroprotective microRNAs (miR-143/145) between endothelial and vascular smooth muscle cells.
- Provided evidence for intercellular miRNA transport influencing atherosclerosis.
Conclusions:
- Intercellular transport of miRNAs via extracellular vesicles is a significant mechanism in cardiovascular homeostasis.
- Targeting miRNA transfer could offer novel therapeutic strategies for atherosclerosis.
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