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Directed remote aromatic metalations: mechanisms and driving forces

David Tilly1, Jakob Magolan, Jacques Mortier

  • 1Eskitis Institute for Cell and Molecular Therapies, Griffith University, Don Young Road, Nathan 4111, Queensland, Australia. dp.tilly@laposte.net

Chemistry (Weinheim an Der Bergstrasse, Germany)
|March 1, 2012
PubMed
Summary

Directed remote aromatic metalations offer efficient synthesis of complex aromatic systems. This review clarifies regioselectivity mechanisms, advancing synthetic chemistry predictability beyond the complex-induced proximity effect (CIPE).

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