Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Organic Compounds03:02

Organic Compounds

All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives01:35

Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives

Just like β-keto acids—which upon thermal decarboxylation form ketones—β-dicarboxylic acids undergo decarboxylation to generate monocarboxylic acids with the liberation of carbon dioxide.
Preparation of Diols and Pinacol Rearrangement01:57

Preparation of Diols and Pinacol Rearrangement

Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides01:16

Nomenclature of Carboxylic Acid Derivatives: Acid Halides, Esters, and Acid Anhydrides

Naming Acid Halides
The IUPAC and common names of acid halides are derived from the corresponding carboxylic acids, by changing “ic acid” to “yl halide.” For example, as shown below, the IUPAC name ethanoyl chloride is derived from ethanoic acid, and the common name, acetyl chloride, is obtained from acetic acid.
Carboxylic Acid Derivatives: Overview01:15

Carboxylic Acid Derivatives: Overview

Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The transcriptional dynamics of TIFY/JAZ and BBX families in jasmonate signaling reveal SlBBX17 as a positive regulator of tomato defense.

Plant cell reports·2026
Same author

The MassBank contributions of the mFam collaboration.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

A sequential MAP kinase cascade regulates mechanical signalling.

Nature communications·2026
Same author

Decoding Plant Metabolism.

Plant physiology·2026
Same author

The Nuclear Effector RIRG190 Interacts with SAS10 to Regulate Arbuscular Mycorrhizal Symbiosis.

International journal of molecular sciences·2025
Same author

Plant metabolism: Zoom in to the single-cell level.

Plant physiology·2025
Same journal

Five undescribed compounds isolated from Gerbera delavayi with their anti-inflammatory activity.

Phytochemistry·2026
Same journal

Ingenane diterpenoids with anti-inflammatory activity from the whole plants of Euphorbia peplus.

Phytochemistry·2026
Same journal

Discovery of cytotoxic 1,4-benzodioxane oxyneolignan analogues from Glechoma longituba.

Phytochemistry·2026
Same journal

Cinnamolides A-G, seven previously undescribed phytoconstituents from the peels of Cinnamomum chago and their anti-inflammatory activity.

Phytochemistry·2026
Same journal

Antiviral amide derivatives from Uvaria siamensis.

Phytochemistry·2026
Same journal

COX-2 inhibitors from Laportea bulbifera: Structure-activity relationship, kinetic investigation, and molecular docking.

Phytochemistry·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Oleanolic acid.

Jacob Pollier1, Alain Goossens

  • 1Department of Plant Systems Biology, VIB, B-9052 Gent, Belgium. jacob.pollier@psb.vib-ugent.be

Phytochemistry
|March 2, 2012
PubMed
Summary
This summary is machine-generated.

Oleanolic acid, a plant-derived compound, shows significant therapeutic potential. Recent advances in understanding its biosynthesis and pharmacology highlight its importance for developing new drugs.

More Related Videos

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Related Experiment Videos

Last Updated: May 24, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
07:36

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea

Published on: December 23, 2022

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid found widely in plants.
  • It occurs as a free acid or as a precursor to saponins, linked to sugar chains.
  • Oleanolic acid and its derivatives exhibit promising pharmacological activities, including hepatoprotective, anti-inflammatory, antioxidant, and anticancer effects.

Purpose of the Study:

  • To review recent progress in oleanolic acid biosynthesis.
  • To discuss the pharmacology of oleanolic acid and its derivatives.
  • To highlight the potential applications of synthetic oleanolic acid derivatives and provide research perspectives.

Main Methods:

  • Literature review of recent studies on oleanolic acid biosynthesis.
  • Analysis of pharmacological data for oleanolic acid and its derivatives.
  • Evaluation of synthetic derivatives and future research directions.

Main Results:

  • Elucidation of oleanolic acid biosynthesis pathways.
  • Demonstration of diverse pharmacological activities (hepatoprotective, anti-inflammatory, antioxidant, anticancer).
  • Identification of potential for synthetic derivatives in drug development.

Conclusions:

  • Oleanolic acid is a compound of significant therapeutic interest.
  • Ongoing research into its biosynthesis and derivatives is crucial for future drug discovery.
  • The commercialization of oleanolic acid-derived drugs underscores its clinical relevance.