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Updated: May 24, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
Published on: November 7, 2017
Note: A high dynamic range, linear response transimpedance amplifier
S Eckel1, A O Sushkov, S K Lamoreaux
1Yale University, Department of Physics, P.O. Box 208120, New Haven, Connecticut 06520-8120, USA. stephen.eckel@yale.edu
Abstract:
We have built a high dynamic range (nine decade) transimpedance amplifier with a linear response. The amplifier uses junction-gate field effect transistors (JFETs) to switch between three different resistors in the feedback of a low input bias current operational amplifier. This allows for the creation of multiple outputs, each with a linear response and a different transimpedance gain. The overall bandwidth of the transimpedance amplifier is set by the bandwidth of the most sensitive range. For our application, we demonstrate a three-stage amplifier with transimpedance gains of approximately 10(9)Ω, 3 × 10(7)Ω, and 10(4)Ω with a bandwidth of 100 Hz.
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