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Nephrotic Syndrome I : Introduction

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...

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Nephrons

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Acute Kidney Injury III: Clinical Manifestations

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Related Experiment Video

Updated: May 24, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Diffuse proliferative crescentic lupus nephritis with normal renal function.

Vibhanshu Gupta¹, Sandeep Sachdeva, Anwar Salamat Khan

¹Department of Nephrology, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia

|March 3, 2012

Summary

Diffuse Proliferative Lupus Nephritis (DPLN) with crescentic changes can present atypically. This case highlights preserved kidney function and nephrotic proteinuria, responding well to treatment.

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Last Updated: May 24, 2026

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Area of Science:

Nephrology
Immunology
Pathology

Background:

Crescentic nephritis is a severe form of kidney disease.
Lupus Nephritis, specifically Diffuse Proliferative Lupus Nephritis (DPLN), often leads to rapid kidney function decline.
Nephrotic range proteinuria is uncommon in crescentic lupus nephritis.

Observation:

A case of DPLN presenting with crescentic changes was observed.
The patient exhibited remarkably preserved renal function.
Nephrotic range proteinuria was a key clinical feature.

Findings:

The biopsy revealed a high frequency of cellular crescents.
Despite severe histological findings, renal function was unexpectedly preserved.
The patient presented with nephrotic range proteinuria.

Implications:

This case challenges the typical poor prognosis associated with crescentic lupus nephritis.
It suggests that preserved renal function and nephrotic proteinuria can occur in DPLN.
Early and aggressive immunosuppressive therapy may lead to excellent outcomes even with extensive crescent formation.