Related Experiment Video
Updated: May 24, 2026

Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns
Published on: December 12, 2025
Undifferentiated carcinoma of the epididymis
Aydin Aydin1, Hamit Zafer Aksoy, Abdulkadir Reis
1Department of Urology, Fatih State Hospital, Trabzon, Turkey. aydinay2@yahoo.com
Abstract:
Epididymal tumors are uncommon and usually benign, with only 25% of them being malignant. Undifferentiated epididymal carcinoma in particular is extremely rare. We report on a 54-year-old male patient presented with right testicular pain and scrotal mass for the last 6 months. Laboratory investigations were unremarkable but epididymal biopsy result was epididymal undifferentiated carcinoma. Inguinal radical orchidectomy was performed and pathological examination of the surgical specimen confirmed the presence of undifferentiated carcinoma. Then, adjuvant chemoradiotherapy (four cycles of cisplatin-etoposide chemotherapy and radiotherapy) was administered. After four months, lung metastases were detected and three doses ifosfamide-Adriamycin chemotherapy were given, but the patient died due to the disease progression. Reports of epididymal undifferentiated carcinoma are extremely rare and the present report emphasizes the need of including epididymal undifferentiated carcinoma in the differential diagnosis of an epididymal mass.
Related Concept Videos
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Cancer
Distribution of Cytoplasmic Content
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
