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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Subclinical hypothyroidism and cognitive dysfunction in the elderly.

F Resta1, V Triggiani, G Barile

  • 1Department of Geriatrics and Rare Diseases Center, University of Bari Aldo Moro, Bari, Italy. f.resta@geriatria.uniba.it

Endocrine, Metabolic & Immune Disorders Drug Targets
|March 6, 2012
PubMed
Summary
This summary is machine-generated.

Subclinical hypothyroidism in the elderly is linked to cognitive decline, increasing the risk of impairment. This condition affects memory and attention, highlighting the need for early detection in older adults.

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Published on: February 14, 2014

Area of Science:

  • Endocrinology
  • Geriatrics
  • Neuroscience

Background:

  • Overt hypothyroidism is known to cause reversible dementia in the elderly.
  • The association between subclinical hypothyroidism and cognitive function in older adults is debated.
  • Cognitive function, particularly long-term memory and selective attention, may be affected by thyroid status.

Purpose of the Study:

  • To investigate the correlation between subclinical hypothyroidism and cognitive function in the elderly.
  • To assess the impact of subclinical hypothyroidism on long-term memory and selective attention.
  • To determine the relationship between thyroid-stimulating hormone (TSH), free thyroxine (FT4), and triiodothyronine (FT3) levels and cognitive performance.

Main Methods:

  • A cohort of 337 outpatients (mean age 74.3 years) was studied, excluding individuals with thyroid dysfunction or those on thyroid-influencing medications.
  • Cognitive function was assessed using the Mini Mental State Examination (MMSE), Prose Memory Test (PMT), and Matrix Test (MT).
  • Statistical analyses were performed to compare cognitive scores between subclinical hypothyroid and euthyroid groups and to examine correlations between hormone levels and cognitive performance.

Main Results:

  • Subclinical hypothyroidism was associated with significantly lower MMSE scores (p<0.03) and a doubled risk of cognitive impairment (RR=2.028, p<0.05).
  • Prose Memory Test scores were significantly lower in subjects with subclinical hypothyroidism (p<0.04).
  • TSH levels showed a negative correlation with MMSE and PMT scores, while FT4 and FT3 levels did not correlate with cognitive measures.

Conclusions:

  • Subclinical hypothyroidism in the elderly is associated with cognitive impairment.
  • The impact of subclinical hypothyroidism on specific cognitive domains like long-term memory and selective attention is less pronounced but present.
  • Thyroid function monitoring may be important for cognitive health in the elderly population.