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[Molecular mechanism of hemosorption]
Voprosy Meditsinskoi Khimii
|July 1, 1990
Summary
Preventive hemosorption in esophageal carcinoma patients did not alter blood counts or protein levels. However, it reduced endotoxicosis and significantly increased lactoferrin, suggesting a key role in hemosorption
Area of Science:
- Biochemistry
- Oncology
- Immunology
Context:
- Esophageal carcinoma patients undergoing chemotherapy and surgery.
- Investigated humoral and intracellular blood components.
- Assessed effects of preventive hemosorption and purulent complications.
Purpose:
- To evaluate the impact of preventive hemosorption on blood components in esophageal carcinoma patients.
- To analyze changes in biochemical indices and protein levels during and after hemosorption.
- To identify the primary modifying mechanism of hemosorption.
Summary:
- Hemosorption did not significantly alter blood counts, protein content, or immunoglobulin levels (IgG, IgA, IgM).
- No hypo- or dysproteinemias were observed following preventive hemosorption.
- Hemosorption normalized biochemical indices, decreasing middle molecular toxins and increasing BAEE activity, indicating reduced endotoxicosis.
- A significant increase in blood plasma lactoferrin (100-200 fold) was observed during hemosorption.
Impact:
- Hemosorption effectively reduces endotoxicosis in cancer patients.
- Lactoferrin, a neutrophil granule component, is identified as a key physiologically active component released during hemosorption.
- Findings suggest lactoferrin release is a primary mechanism modifying hemosorption's therapeutic effect.