Hyphenated liquid chromatography-gas chromatography technique: recent evolution and applications.
Giorgia Purcaro1, Sabrina Moret, Lanfranco Conte
1Dipartimento di Scienze degli Alimenti, Università di Udine, Italy. giopurcaro@libero.it
Journal of Chromatography. A
|March 6, 2012
Summary
This review covers advancements in liquid chromatography-gas chromatography (LC-GC) interfaces over the last decade. It highlights improved interfaces and techniques for analyzing water-based samples using reverse-phase LC-GC.
Area of Science:
- Analytical Chemistry
- Chromatography
Background:
- Liquid chromatography (LC) and gas chromatography (GC) hyphenation was introduced in 1979.
- Extensive research has explored various interfaces for coupling normal-phase (NP) and reverse-phase (RP) LC with GC.
Purpose of the Study:
- To review technical progress and applications of LC-GC interfaces in the last decade.
- To describe commonly used LC-GC interfaces and recent developments.
Main Methods:
- Focus on technical advancements and applications of LC-GC.
- Description of interfaces, particularly programmed temperature vaporizer (PTV) injectors.
- Optimization of reverse-phase LC-GC coupling for aqueous samples.
Main Results:
- Development of more flexible interfaces, including PTV injectors, has enhanced LC-GC usability.
- Significant efforts have been made to optimize reverse-phase LC-GC for water-based samples.
- Comprehensive two-dimensional LC×GC approaches are also discussed.
Conclusions:
- LC-GC technology has evolved significantly, with a focus on improved interfaces and broader applicability.
- Recent advancements facilitate the analysis of challenging samples, such as water-based matrices.
- Future perspectives for LC-GC and LC×GC techniques are promising.
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