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Updated: May 24, 2026

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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O-GlcNAcylation of a circadian clock protein: dPER taking its sweet time
Axel C R Diernfellner1, Michael Brunner
1University of Heidelberg Biochemistry Center, Heidelberg, Germany.
Abstract:
In this issue of Genes & Development, Kim and colleagues (pp. 490-502) report that the Drosophila circadian repressor dPER undergoes O-linked GlcNAcylation (O-GlcNAc). Their data show that manipulation of the relevant O-GlcNAc transferase (OGT) regulates behavioral rhythmicity by affecting the stability and nuclear translocation of dPER.
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