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[Effects of trospium chloride on the lower urinary tract function]
T Suzuki1, O Nishizawa, K Sugaya
1Department of Urology, Akita University School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|September 1, 1990
Summary
Trospium chloride reduced bladder pressure and increased residual urine in dogs, suggesting it may help with overactive bladder symptoms by acting as an antimuscarinic agent.
Area of Science:
- Pharmacology
- Urology
- Neuroscience
Context:
- Investigating lower urinary tract function in decerebrated dogs.
- Utilizing combined cystometry and sphincter electromyogram for urodynamic assessment.
- Examining the effects of drug administration before and after induced micturition.
Purpose:
- To evaluate the impact of trospium chloride on bladder pressure and voiding efficiency.
- To determine the dose-dependent effects of trospium chloride on urodynamic parameters.
- To elucidate the potential antimuscarinic mechanism of trospium chloride in lower urinary tract function.
Summary:
- Trospium chloride (0.1 mg/kg) significantly decreased threshold pressure during bladder filling.
- Doses of 0.03, 0.1, and 0.3 mg/kg significantly reduced maximum bladder pressure during voiding.
- A dose of 0.3 mg/kg significantly increased residual urine, indicating impaired bladder emptying.
- The drug likely functions as an antimuscarinic agent, impacting cholinergic activity.
Impact:
- Trospium chloride demonstrates potential therapeutic value for managing symptoms of hyperactive bladder.
- Findings contribute to understanding the pharmacological effects on lower urinary tract physiology.
- Provides evidence for the antimuscarinic properties of trospium chloride in a preclinical model.