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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
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Related Experiment Video

Updated: May 24, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

Electrochemotherapy: Progress and Prospects.

Jean-Michel Escoffre1, Marie-Pierre Rols

  • 1UMRS Inserm U930 "Imagerie et Cerveau" - CNRS ERL3106, Université François Rabelais de Tours, CHU Le Bretonneau, 10 ter bd Tonnellé, 37044 Tours Cedex 9 - France. jean-michel.escoffre@univ-tours.fr; rols@ipbs.fr.

Current Pharmaceutical Design
|March 9, 2012
PubMed
Summary
This summary is machine-generated.

Electrochemotherapy (ECT) offers an effective palliative treatment for unresectable tumors, significantly increasing drug delivery to cancer cells. This loco-regional therapy shows high response rates and good cosmetic outcomes for challenging tumor nodules.

Related Experiment Videos

Last Updated: May 24, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

Area of Science:

  • Oncology
  • Medical Physics
  • Pharmacology

Background:

  • Recurrent or unresectable cutaneous and subcutaneous tumors present significant therapeutic challenges.
  • Standard treatments often fail or are insufficient for these advanced tumor types.

Purpose of the Study:

  • To evaluate electrochemotherapy (ECT) as a palliative treatment for unresectable cutaneous and subcutaneous tumors.
  • To highlight the mechanism and efficacy of ECT in enhancing anti-cancer drug delivery.

Main Methods:

  • ECT involves local application of electric pulses to tumor cells to increase drug permeability.
  • Antineoplastic drugs like cisplatin or bleomycin are administered intravenously or intratumorally.
  • Electric pulses transiently enhance cancer cell permeability to poorly permeant anti-tumor drugs up to a hundred-fold.

Main Results:

  • ECT demonstrates high overall objective response rates of approximately 80-90% for palliative treatment.
  • The therapy provides satisfactory cosmetic results for treated tumor nodules.
  • ECT is an efficient loco-regional therapy for unresectable recurrent tumor nodules.

Conclusions:

  • Electrochemotherapy is an effective loco-regional therapy for palliative treatment of unresectable recurrent tumor nodules.
  • Future challenges include treating deep-seated tumors and metastases.
  • Combining ECT with gene electrotransfer or electro-photodynamic therapy may offer promising strategies for cancer eradication.