Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Circadian Rhythms and Gene Regulation

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

Biological Clocks and Seasonal Responses

Biological Clocks and Seasonal Responses

The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.

Meiosis II

Meiosis II

Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The oocytes of basal dermapterans lack the posterior pole lysosomal compartment (PPLC).

Developmental biology·2026

Same author

Targeting the cell membrane in established and emerging model organisms.

Development (Cambridge, England)·2026

Same author

Targeting the cell membrane in established and emerging model organisms.

bioRxiv : the preprint server for biology·2025

Same author

The Ring-Legged Earwig, Euborellia annulipes (Dermaptera, Insecta): A Promising Model to Study Development and Reproductive Strategies of Hemimetabolous Insects.

Results and problems in cell differentiation·2025

Same author

Long-term live imaging, cell identification and cell tracking in regenerating crustacean legs.

eLife·2025

Same author

The crustacean Parhyale.

Nature methods·2022

Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026

Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026

Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026

Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026

Same journal

Retraction.

Science (New York, N.Y.)·2026

Same journal

Making time.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 24, 2026

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

A segmentation clock with two-segment periodicity in insects.

Andres F Sarrazin¹, Andrew D Peel, Michalis Averof

¹Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Nikolaou Plastira 100, GR-70013 Heraklio, Crete, Greece.

Science (New York, N.Y.)

|March 10, 2012

Summary

This summary is machine-generated.

The segmentation gene odd-skipped (Tc-odd) oscillates cyclically during beetle development. This finding demonstrates that molecular oscillators are a shared feature of segmentation across diverse animal groups.

More Related Videos

A Computational Method to Quantify Fly Circadian Activity

A Computational Method to Quantify Fly Circadian Activity

Published on: October 28, 2017

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Published on: January 19, 2018

Related Experiment Videos

Last Updated: May 24, 2026

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Generation of Dispersed Presomitic Mesoderm Cell Cultures for Imaging of the Zebrafish Segmentation Clock in Single Cells

Published on: July 24, 2014

A Computational Method to Quantify Fly Circadian Activity

A Computational Method to Quantify Fly Circadian Activity

Published on: October 28, 2017

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Published on: January 19, 2018

Area of Science:

Developmental biology
Evolutionary biology
Genetics

Background:

Vertebrate segmentation involves oscillating gene expression.
The role of such oscillations in arthropod segmentation remains debated.
Previous studies lacked definitive evidence for cyclic gene expression in arthropod segmentation.

Purpose of the Study:

To investigate the presence and dynamics of gene oscillations during arthropod segmentation.
To provide rigorous proof of cyclic gene expression in a model insect.
To compare segmentation mechanisms between arthropods and vertebrates.

Main Methods:

Studied the segmentation gene odd-skipped (Tc-odd) in the beetle Tribolium castaneum.
Utilized embryo bisection and differential culture intervals to determine gene cycling period.
Employed live imaging and cell tracking in green fluorescent protein-expressing embryos to rule out cell movement artifacts.

Main Results:

Demonstrated that Tc-odd oscillates with a two-segment periodicity.
Determined the oscillation period to be approximately 95 minutes at 30°C.
Confirmed that cell movements do not account for the observed dynamic Tc-odd expression patterns.

Conclusions:

Molecular oscillators are a conserved mechanism in the segmentation of divergent animal phyla.
This finding reconciles contrasting views on insect and vertebrate segmentation mechanisms.
Provides a unified view of segmentation evolution.