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Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Spinal Cord: Gross Anatomy01:15

Spinal Cord: Gross Anatomy

The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.

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Updated: May 24, 2026

Calibrated Forceps Model of Spinal Cord Compression Injury
09:41

Calibrated Forceps Model of Spinal Cord Compression Injury

Published on: April 24, 2015

Using the Spinal Cord Injury Common Data Elements.

Fin Biering-Sørensen1, Susan Charlifue, Michael J Devivo

  • 1Clinic for Spinal Cord Injuries, NeuroScience Centre, Rigshospitalet, Copenhagen, Denmark.

Topics in Spinal Cord Injury Rehabilitation
|March 13, 2012
PubMed
Summary

Standardized data elements for spinal cord injury (SCI) research are being developed. These common data elements (CDEs) aim to improve data quality, sharing, and clinical trial efficiency for SCI therapeutics and rehabilitation.

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A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
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A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

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Last Updated: May 24, 2026

Calibrated Forceps Model of Spinal Cord Compression Injury
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A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury
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A Novel Vertebral Stabilization Method for Producing Contusive Spinal Cord Injury

Published on: January 5, 2015

Area of Science:

  • Neurology
  • Clinical Research Data Standards
  • Spinal Cord Injury

Background:

  • International Spinal Cord Injury (SCI) Data Sets provide a framework for clinical research.
  • Existing data sets are being enhanced with standardized data elements.
  • The National Institute of Neurological Disorders and Stroke (NINDS) initiated a Common Data Element (CDE) Project.

Purpose of the Study:

  • To develop data standards for SCI clinical research.
  • To create variable names and database structures for SCI data sets.
  • To improve the efficiency, effectiveness, and data quality of SCI studies and treatments.

Main Methods:

  • Development of Common Data Elements (CDEs) for SCI research by the NINDS CDE Project team.
  • Creation of variable names and database structures for International SCI Data Sets.
  • Exemplification using the International SCI Core Data Set and the International SCI Cardiovascular Function Basic Data Set.

Main Results:

  • Established SCI CDEs with defined variable names and database structures.
  • Demonstrated consistency and potential for electronic medical information transfer.
  • Identified pilot testing as crucial for validating the SCI CDE initiative.

Conclusions:

  • The SCI CDE initiative aims to enhance clinical research efficiency, data quality, and inter-center data sharing.
  • Standardized data elements facilitate the testing of novel SCI therapeutics and rehabilitation strategies.
  • Successful implementation of SCI CDEs is vital for advancing SCI clinical treatment and investigation.