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Updated: May 24, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Cardiovascular drift during heat stress: implications for exercise prescription
Jonathan E Wingo1, Matthew S Ganio, Kirk J Cureton
1Department of Kinesiology, University of Alabama, Tuscaloosa, AL 35487-0312 USA. jwingo@bamaed.ua.edu
Abstract:
Cardiovascular drift, the progressive increase in heart rate and decrease in stroke volume that begins after approximately 10 min of prolonged moderate-intensity exercise, is associated with decreased maximal oxygen uptake, particularly during heat stress. Consequently, the increased heart rate reflects an increased relative metabolic intensity during prolonged exercise in the heat when cardiovascular drift occurs, which has implications for exercise prescription.
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