Related Experiment Video
Updated: May 24, 2026
Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
Published on: November 27, 2013
A butyl methacrylate monolithic column prepared in-situ on a microfluidic chip and its applications
Yi Xu1, Wenpin Zhang, Ping Zeng
1National Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, and International R&D Center of Micro-Nano Systems and New Materials Technology, and Microsystem Research Center, and College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China; E-mails: zhang wenpinchina@yahoo.com.cn (W.-P.Z.); zp860128@163.com (P. Z.); tianmao6971@163.com (Q. C.).
Abstract:
A butyl methacrylate (BMA) monolithic column was polymerized in-situ with UV irradiation in an ultraviolet transparent PDMS micro-channel on a homemade micro-fluidic chip. Under the optimized conditions and using a typical polymerization mixture consisting of 75% porogenic solvents and 25% monomers, the BMA monolithic column was obtained as expected. The BET surface area ratio of the BMA monolithic column was 366 m(2)·g(-1). The corresponding SEM images showed that the monolithic column material polymerized in a glass channel was composed of uniform pores and spherical particles with diameters ranging from 3 to 5 μm. The promethazine-luminal-potassium ferricyanide chemiluminescence system was selected for testing the capability of the column. A flow injection analytical technique-chemiluminescence (FIA-CL) system on the microfluidic chip with a BMA monolithic column pretreatment unit was established to determine promethazine. Trace promethazine was enriched by the BMA monolithic column, with more than a 10-fold average enrichment ratio. The proposed method has a linear response concentration range of 1.0×10(-8) - 1.0×10(-6)g·mL(-1) and the detection limit was 1.6×10(-9)g·mL(-1).
