Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lovastatin. Warfarin interaction.

¹Cardio-Diagnostic Clinique, Fairmont, WVa 26554.

Archives of Internal Medicine

|November 1, 1990

Summary

This summary is machine-generated.

Lovastatin and warfarin can cause dangerous bleeding by lowering prothrombin levels. Doctors should monitor prothrombin time closely in patients taking both drugs to prevent hypoprothrombinemia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways.

The Journal of biological chemistry·2001

Same author

Biliary atresia in an infant born to an HIV positive mother.

Sexually transmitted infections·2001

Same author

Phylogenetic analysis of gram-positive bacteria based on grpE, encoded by the dnaK operon.

International journal of systematic and evolutionary microbiology·2000

Same author

Low levels of ethanol stimulate and high levels decrease phosphorylation in microtubule-associated proteins in rat brain: an in vitro study.

Alcohol and alcoholism (Oxford, Oxfordshire)·2000

Same author

Bioreactivity of glutathionyl hydroquinone with implications to benzene toxicity.

Toxicology·2000

Same author

Two new diterpenoids from Salvia triloba.

Fitoterapia·2000

Area of Science:

Pharmacology
Drug Interactions
Clinical Medicine

Background:

Warfarin is a common anticoagulant medication.
Lovastatin is a widely prescribed statin for cholesterol management.
Drug interactions between anticoagulants and statins require careful consideration.

Observation:

Two patients experienced hypoprothrombinemia and bleeding.
The adverse events were linked to concurrent use of lovastatin and warfarin.

Findings:

The combination of lovastatin and warfarin led to a significant drug interaction.
Hypoprothrombinemia, a condition of reduced prothrombin, was observed in affected patients.

Implications:

Heightened clinical awareness of this lovastatin-warfarin interaction is crucial.

Related Experiment Videos

Prothrombin time monitoring is essential for patients on warfarin and lovastatin.

This interaction highlights the need for vigilant patient monitoring in polypharmacy.