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Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Updated: May 24, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Cancer proteomics.

Hwee Tong Tan1, Yie Hou Lee, Maxey C M Chung

  • 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Mass Spectrometry Reviews
|March 17, 2012
PubMed
Summary
This summary is machine-generated.

Proteomics research in cancer aims to find biomarkers for early detection and personalized medicine. This involves analyzing proteins from various samples using advanced techniques to understand cancer biology.

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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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Related Experiment Videos

Last Updated: May 24, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
10:37

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Oncoproteomics
  • Cancer Biology
  • Biomarker Discovery

Background:

  • Cancer's high global mortality is linked to its complexity and lack of early diagnostic biomarkers.
  • Identifying functional proteins driving malignancy is crucial for advancing cancer research.
  • Proteomics offers a pathway to discover biomarkers for diagnosis, prognosis, and treatment efficacy.

Purpose of the Study:

  • To identify and characterize functional proteins in cancer (oncoproteome).
  • To discover biomarkers for early cancer detection, prognosis, and therapy response.
  • To advance personalized medicine through a deeper understanding of cancer biology.

Main Methods:

  • Utilizing diverse human samples including cell lines, tissues, and biofluids (plasma/serum).
  • Employing a wide array of proteomics tools for protein identification, quantitation, and enrichment.
  • Developing innovative proteomics technologies for in-depth oncoproteome analysis.

Main Results:

  • Identification of key proteins involved in tumorigenesis.
  • Discovery of potential biomarkers for various clinical applications.
  • Elucidation of molecular mechanisms underlying cancer development.

Conclusions:

  • Proteomics is essential for uncovering cancer's complexities and identifying actionable biomarkers.
  • Advanced proteomics technologies are vital for deep oncoproteome investigation.
  • High-throughput validation and data integration are needed to fully leverage oncoproteomics for clinical impact.