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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the atmosphere, the...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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Published on: September 17, 2016

Nutrient sensing and the circadian clock.

Clara B Peek1, Kathryn M Ramsey, Biliana Marcheva

  • 1Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Chicago, IL 60611, USA.

Trends in Endocrinology and Metabolism: TEM
|March 20, 2012
PubMed
Summary
This summary is machine-generated.

The body's internal clock (circadian system) regulates energy use with daily light changes. Nutrient signals, like those from high-fat diets, interact with this clock, influencing metabolism.

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Last Updated: May 24, 2026

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

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Area of Science:

  • Chronobiology
  • Metabolic regulation
  • Nutrient signaling

Background:

  • The circadian system synchronizes physiological processes with the daily light-dark cycle.
  • Molecular clocks, both neural and peripheral, regulate energy storage and utilization.
  • Emerging evidence suggests nutrient signals influence circadian clock function.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying the interplay between metabolic and circadian pathways.
  • To highlight the role of nutrient signals in integrating these two systems.

Main Methods:

  • Review of recent studies on circadian rhythms and metabolism.
  • Analysis of nutrient signals, including peptidergic hormones and macromolecules.
  • Investigation of high-fat diet effects on circadian clock properties.

Main Results:

  • Circadian clocks respond to nutrient cues.
  • High-fat diets can alter the period of locomotor activity, a key clock property.
  • Peptidergic hormones and macromolecules act as nutrient signals.

Conclusions:

  • There is a reciprocal relationship between metabolic and circadian pathways.
  • Nutrient signals are crucial integrators of circadian and metabolic systems.
  • Understanding these molecular links is vital for metabolic health.