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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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Related Experiment Video

Updated: May 24, 2026

Generation of Human CD40-activated B cells
13:27

Generation of Human CD40-activated B cells

Published on: October 16, 2009

CD40 and tolerance induction.

Mohammad Hossein Karimi1, Ali Akbar Pourfathollah

  • 1Department of Immunology, Tarbiat Modares University of Mesdical Science, Tehran, Iran.

Iranian Journal of Allergy, Asthma, and Immunology
|March 20, 2012
PubMed
Summary
This summary is machine-generated.

The CD40-CD40L pathway regulates immune responses and is implicated in diseases. Modulating this interaction offers potential for immunotherapy in conditions like autoimmune diseases and transplant rejection.

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Murine Model of CD40-activation of B cells
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18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

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Last Updated: May 24, 2026

Generation of Human CD40-activated B cells
13:27

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Published on: October 16, 2009

Murine Model of CD40-activation of B cells
12:24

Murine Model of CD40-activation of B cells

Published on: March 5, 2010

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathology

Background:

  • CD40, a tumor necrosis factor receptor superfamily member, is expressed on immune and non-immune cells.
  • Its interaction with CD40 ligand (CD154) critically regulates cellular and humoral immunity.
  • The CD40-CD154 pathway plays a significant role in host defense and disease pathogenesis.

Purpose of the Study:

  • To review the multifaceted roles of CD40-CD40L interactions.
  • To explore CD40's involvement in dendritic cell regulation and tolerance induction.
  • To examine CD40's contribution to autoimmune diseases and allograft rejection.

Main Methods:

  • Literature review focusing on CD40-CD40L signaling.
  • Analysis of CD40's role in dendritic cell function and immune tolerance.
  • Investigation of CD40's involvement in autoimmune pathology and transplant rejection.

Main Results:

  • CD40-CD40L interactions influence dendritic cell maturation and function.
  • Dysregulation of CD40 signaling contributes to autoimmune diseases.
  • The CD40 pathway is a key factor in allograft rejection and immune tolerance induction.

Conclusions:

  • CD40-CD40L interactions are pivotal in immune regulation and disease.
  • Targeting the CD40 pathway holds promise for immunotherapeutic strategies.
  • Understanding CD40's role is crucial for managing autoimmune disorders and improving transplant outcomes.