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Acral peeling skin syndrome in two East-African siblings: case report
Samson K Kiprono1, Baraka M Chaula, Bernard Naafs
1Department of Dermatology, Regional Dermatology Training Center at KCMC, Box 8332, Moshi, Tanzania. kipsam2@yahoo.com
Background:
Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense mutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the stratum granulosum.
Case Presentation:
We present a case of two siblings who developed continuous peeling of the palms and soles from the first year of life. This peeling was more severe on the soles than palms and on younger sibling than elder sibling. Peeling is worsened by occlusion and sweating.
Conclusions:
Sporadic cases of Acral Peeling Skin Syndrome occur in African population. There is variability in time of presentation and clinical severity even within families.
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