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Related Experiment Video

Updated: May 23, 2026

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

Multiple electrosprays generated from a single polycarbonate microstructured fibre.

Graham T T Gibson1, Ramin D Wright, Richard D Oleschuk

  • 1Department of Chemistry, Queen's University, Kingston, Ontario, Canada, K7L 3N6.

Journal of Mass Spectrometry : JMS
|March 21, 2012
PubMed
Summary
This summary is machine-generated.

Multiple electrosprays (MESs) enhance mass spectrometry sensitivity. Novel microstructured fiber emitters increase signal by splitting a single flow into multiple nanoelectrosprays, improving biomolecule detection.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Materials Science

Background:

  • Electrospray ionization (ESI) is crucial for sensitive biomolecule detection in mass spectrometry.
  • Lower flow rates in nanoESI improve ionization efficiency and signal intensity.
  • Generating multiple electrosprays (MESs) from a single sample enhances sensitivity without reducing flow rate.

Purpose of the Study:

  • To develop and evaluate novel microstructured fiber (MSF) emitters for multiple electrosprays (MESs).
  • To demonstrate the principle of signal enhancement using radially arranged channels in MSF emitters.
  • To assess the compatibility of these emitters with standard nanoESI and mass spectrometry (MS) equipment.

Main Methods:

  • Fabrication of custom MSF emitters with 3, 6, 9, and 12 radially arranged channels using polycarbonate.
  • Characterization of emitter dimensions for compatibility with nanoESI and MS orifices.
  • Measurement of spray current under consistent solvent, voltage, and total flow rate conditions.

Main Results:

  • The spray current demonstrated a clear dependence on the square root of the number of holes (independent electrosprays).
  • The MSF emitters showed compatibility with existing nanoESI and MS instrumentation.
  • The radial arrangement of channels effectively prevented electric field inhomogeneities.

Conclusions:

  • The developed MSF emitters provide a viable proof of principle for enhancing mass spectrometry sensitivity through MES.
  • Further development in alternative materials and increased channel density is warranted for greater signal enhancement.
  • This technology offers a promising approach for improving biomolecule detection limits in mass spectrometry.