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Two cases of transfusion-transmitted Anaplasma phagocytophilum

Kyle Annen1, Kenneth Friedman, Camellia Eshoa

  • 1BloodCenter of Wisconsin, Milwaukee, 53233, USA.

American Journal of Clinical Pathology
|March 21, 2012
PubMed

Insights

Transfusion transmission of Anaplasma phagocytophilum, a tick-borne illness, is rare despite high prevalence. Leukocyte reduction filtration did not prevent transmission in two reported cases of human granulocytic anaplasmosis.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Anaplasma phagocytophilum causes human granulocytic anaplasmosis, typically transmitted by ticks.
  • High seroprevalence suggests frequent transfusion transmission, yet few cases are documented.

Observation:

  • Two new cases of Anaplasma phagocytophilum transfusion transmission are reported.
  • Leukocyte reduction filtration of blood products did not prevent transmission in these instances.

Findings:

  • Leukocyte reduction, a common blood safety measure, may not fully prevent Anaplasma phagocytophilum transmission.
  • The discrepancy between expected and reported transfusion transmission rates remains unexplained.

Implications:

  • Re-evaluation of blood safety protocols for Anaplasma phagocytophilum may be necessary.
  • Further research is needed to understand transmission dynamics and optimize prevention strategies.

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