Related Experiment Video
Updated: May 23, 2026
08:53
In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
Published on: September 16, 2019
Engineering antibodies for cancer therapy.
1Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996-2200, USA. boder@utk.edu
Annual Review of Chemical and Biomolecular Engineering
|March 22, 2012
Summary
Modern antibody engineering has revolutionized cancer therapy, driving innovation in antibody-based drugs. Research focuses on improving therapeutic mechanisms, overcoming challenges, and developing next-generation biopharmaceuticals.
Area of Science:
- Biopharmaceutical development
- Cancer immunotherapy
- Antibody engineering
Background:
- The last 13 years have seen significant success in antibody-based cancer therapies following the first FDA approval.
- Active research is ongoing to develop improved antibody drugs for cancer treatment.
- Diverse antibody discovery and engineering tools have been developed over the past two decades.
Purpose of the Study:
- To summarize monoclonal antibody therapeutic mechanisms.
- To outline challenges in antibody-based cancer treatment.
- To review current antibody engineering technologies and future concepts for next-generation biopharmaceuticals.
Main Methods:
- Literature review of antibody engineering technologies.
- Analysis of therapeutic mechanisms of monoclonal antibodies.
- Discussion of challenges and future directions in antibody-based cancer therapy.
Main Results:
- Monoclonal antibodies have demonstrated success in cancer therapy.
- Various engineering tools exist for antibody discovery and optimization.
- New antibody formats and alternatives are being explored.
Conclusions:
- Antibody engineering is crucial for advancing cancer biotherapeutics.
- Overcoming treatment challenges and innovating antibody formats are key research areas.
- Next-generation antibody-based drugs hold promise for improved cancer treatment outcomes.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
01:30Cancer Vaccines
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...