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Published on: January 7, 2019
[Periaortic abscess and infective endocarditis: beware of this dangerous duo]
D Benzarouel1, F Ouanan, D Boumzebra
1Service de cardiologie, hôpital Ibn Tofail, CHU Mohamed VI, Marrakech, Maroc. benzaroual.dounia@hotmail.com
Objective:
To determine clinical, echocardiographic features, management and outcomes of patients presenting peri aortic abscess complicating infective endocarditis (IE) and demonstrate the impact of periaortic abscess on morbidity and mortality of these patients.
Methods:
We have analyzed clinical, microbiological, echocardiographic aspects, therapies and outcomes of patients with aortic abscess occurring during IE, and we compared these data with those of patients presenting IE without peri aortic abscess in the same period in the cardiology department of the University Hospital of Marrakech from January 2006 to January 2010.
Results:
Above 56 cases of infective endocarditis, 16 patients had an aortic abscess. Mean age was 33 ± 11 years with a clear male predominance in the group IE with abscess versus IE without abscess. Heart failure was noted in all patients in periaortic abscess group, and was more severe in this group compared to control. Streptococcus and staphylococcus predominated with no significant difference between the two groups. Transthoracic echocardiography coupled with transesophageal echocardiography made the diagnosis of aortic abscess witch was isolated in 11 cases and associated with other complications in five cases. In terms of complications, splenic infarction was more frequent in the group with abscess (25 versus 2.5%, P<0.05). There was not a significant difference between the two groups for the others complications. Surgery associated with a double antibiotic therapy was the standard treatment with a variable delay for surgery of four days to four weeks. Hospital mortality in the acute phase was higher in periaortic abscess group (37% versus 10%, P<0.05). The evolution of survivors at six months was favorable.
Conclusion:
Periaortic abscess complicating IE is associated with a high morbidity and mortality in spite of modern approach as well as on medical or surgical treatment. It requires therefore a strict monitoring of patients with infective endocarditis.
Insights
Periaortic abscess complicating infective endocarditis (IE) significantly increases morbidity and mortality. Early diagnosis and monitoring are crucial for managing these high-risk patients.
Area of Science:
- Cardiology
- Infectious Diseases
- Surgical Pathology
Background:
- Infective endocarditis (IE) can lead to severe complications, including peri-aortic abscess formation.
- Peri-aortic abscesses represent a significant challenge in the management of IE, impacting patient outcomes.
Purpose of the Study:
- To investigate the clinical and echocardiographic features of patients with peri-aortic abscess complicating IE.
- To evaluate the management strategies and outcomes for these patients.
- To determine the impact of peri-aortic abscess on IE-related morbidity and mortality.
Main Methods:
- A comparative study analyzing clinical, microbiological, and echocardiographic data.
- Inclusion of patients with IE and peri-aortic abscesses and a control group with IE alone.
- Data collected from January 2006 to January 2010 at the University Hospital of Marrakech.
Main Results:
- 16 out of 56 IE patients developed a peri-aortic abscess, predominantly males.
- All abscess patients experienced heart failure, often more severe than in the control group.
- Higher hospital mortality (37% vs. 10%) and increased splenic infarction rates were observed in the abscess group.
Conclusions:
- Peri-aortic abscess in IE is linked to substantial morbidity and mortality, even with modern treatments.
- Aggressive monitoring and timely intervention are essential for patients with IE and suspected peri-aortic abscess.
- Despite challenges, survivors showed favorable outcomes at six months.
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