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Updated: May 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Scleroderma-like syndrome due to hydroxyurea.

F J García-Martínez1, J García-Gavín, A Alvarez-Pérez

  • 1Department of Dermatology, Faculty of Medicine, Complejo Hospitalario Universitario, Santiago de Compostela, Spain. fjgarcia@aedv.es

Clinical and Experimental Dermatology
|March 24, 2012
PubMed
Summary
This summary is machine-generated.

Hydroxyurea (HU) treatment may cause scleroderma-like skin changes. This case report details a patient whose skin condition resolved after HU withdrawal, suggesting a causal link.

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Last Updated: May 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

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Published on: June 16, 2020

Area of Science:

  • Dermatology
  • Oncology
  • Pharmacology

Background:

  • Scleroderma-like cutaneous changes are associated with various drugs.
  • Hydroxyurea (HU), a medication for myeloproliferative disorders, has not been previously linked to such effects.
  • This study investigates a potential association between HU and scleroderma-like skin reactions.

Observation:

  • A 67-year-old man on long-term HU therapy for a myeloproliferative disorder developed progressive, pruritic, woody induration on both legs.
  • The patient also presented with Gottron-like papules and a squamous cell carcinoma.
  • Skin biopsy revealed massive dermal fibrosis.

Findings:

  • The patient's scleroderma-like skin changes resolved completely within six months of discontinuing HU.
  • Histological examination confirmed significant dermal fibrosis consistent with scleroderma.
  • This case suggests a potential causal relationship between hydroxyurea and sclerodermiform skin changes.

Implications:

  • Scleroderma-like syndrome should be considered a potential side effect of hydroxyurea.
  • This finding may impact the management of patients on long-term HU therapy.
  • Further research is warranted to confirm this association and elucidate the underlying mechanisms.